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Plasmonic ZnO nanorods/Au substrates for protein microarrays with high sensitivity and broad dynamic range.
- Source :
-
Sensors & Actuators B: Chemical . Jun2016, Vol. 228, p231-236. 6p. - Publication Year :
- 2016
-
Abstract
- Microarrays require high sensitivity and a broad dynamic range for high-throughput diagnostics and proteomic analysis. We present the fabrication of novel plasmonic protein microarrays using nanostructured ZnO-Nanorods (ZnO-NRs) on 50 nm Au film that exhibits an enhancement of fluorescence up to 200-fold. The as-prepared plasmonic protein microarrays were used for the detection of the carcinoembryonic antigen (CEA) cancer biomarker. The plasmonic enhancement resulted in a detection limit of 27 pg mL −1 in 0.01 M PBS and a dynamic range of 100 pg mL −1 to 100 μg mL −1 . The ZnO-NRs/Au substrates can be mass-manufactured, which is highly promising for the development of low cost, sensitive, and high-throughput protein assay platform for applications in clinical diagnosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PLASMONICS
*ZINC oxide
*NANORODS
*GOLD compounds
*SUBSTRATES (Materials science)
Subjects
Details
- Language :
- English
- ISSN :
- 09254005
- Volume :
- 228
- Database :
- Academic Search Index
- Journal :
- Sensors & Actuators B: Chemical
- Publication Type :
- Academic Journal
- Accession number :
- 113477936
- Full Text :
- https://doi.org/10.1016/j.snb.2016.01.019