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The effect of induced hypertension on neurological outcome in forebrain ischaemia model in rats.
- Source :
-
Injury . Mar2016, Vol. 47 Issue 3, p605-608. 4p. - Publication Year :
- 2016
-
Abstract
- <bold>Introduction: </bold>The present study investigated the effects of induced hypertension on hippocampal cell death after forebrain ischaemia in rats.<bold>Materials and Methods: </bold>In this study, forebrain ischaemia was induced in 20 Sprague-Dawley rats by clamping the bilateral common carotid arteries to induce systemic hypotension for 8min. All rats then underwent reperfusion during which the induced hypertension group (n=10) received intermittent intravenous injections of phenylephrine (5μg) to maintain their mean arterial blood pressure at 20mmHg above baseline for 10min and the control group (n=10) did not receive any treatment. In both groups, the numbers of viable and apoptotic neuronal cells in the cornu ammonis 1 (CA1) area of the hippocampus were evaluated 7 days after the induction of ischaemia.<bold>Results: </bold>The mean percentage of viable neuronal cells was higher in the induced hypertension group than in the control group (35% vs. 26%, respectively; p=0.004), but there was no significant difference in the proportion of apoptotic neuronal cells between the groups (57% vs. 43%, respectively; p=0.165).<bold>Conclusions: </bold>Induced hypertension significantly attenuated necrotic cell death in the hippocampal CA1 area, but apoptotic cell death was not affected. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTICS
*HYPERTENSION
*NEUROLOGY
*HEALTH outcome assessment
*PROSENCEPHALON
*ISCHEMIA
*LABORATORY rats
*ANIMAL experimentation
*APOPTOSIS
*BIOLOGICAL models
*BRAIN
*CEREBRAL ischemia
*COMPARATIVE studies
*HIPPOCAMPUS (Brain)
*RESEARCH methodology
*MEDICAL cooperation
*NEURONS
*RATS
*RESEARCH
*OXIDATIVE stress
*TRANSIENT ischemic attack
*EVALUATION research
*NEUROPROTECTIVE agents
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 00201383
- Volume :
- 47
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Injury
- Publication Type :
- Academic Journal
- Accession number :
- 113592852
- Full Text :
- https://doi.org/10.1016/j.injury.2015.11.003