Back to Search
Start Over
Visible-Light-Promoted Trifluoromethylthiolation of Styrenes by Dual Photoredox/Halide Catalysis.
- Source :
-
Chemistry - A European Journal . Mar2016, Vol. 22 Issue 13, p4395-4399. 5p. - Publication Year :
- 2016
-
Abstract
- Herein, we report a new visible-light-promoted strategy to access radical trifluoromethylthiolation reactions by combining halide and photoredox catalysis. This approach allows for the synthesis of vinyl-SCF3 compounds of relevance in pharmaceutical chemistry directly from alkenes under mild conditions with irradiation from household light sources. Furthermore, alkyl-SCF3-containing cyclic ketone and oxindole derivatives can be accessed by radical-polar crossover semi-pinacol and cyclization processes. Inexpensive halide salts play a crucial role in activating the trifluoromethylthiolating reagent towards photoredox catalysis and aid the formation of the SCF3 radical. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHOTOCATALYSIS
*VISIBLE spectra
*STYRENE
*HALIDES
*PHOTOCATALYSTS
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 22
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 113737987
- Full Text :
- https://doi.org/10.1002/chem.201600190