Back to Search
Start Over
The Synthesis of Both Diastereomers of 5′-Methylhomoaristeromycin.
- Source :
-
Nucleosides, Nucleotides & Nucleic Acids . 2016, Vol. 35 Issue 3, p105-113. 9p. - Publication Year :
- 2016
-
Abstract
- The preparation of the C-5′ diastereomers of 5′-homoaristeromycin has been achieved in 6 steps beginning with readily available (3aR,6aR)-2,2-dimethyl-2H,3aH,4H,6aH-cyclopenta[1,3]dioxol-4-one in a Michael reaction employing chiral Evans N-acyloxazolidinones that served to direct the requisite side chain stereochemistry. The two targets were evaluated against a battery of viruses and found to possess activity only towards yellow fever. Both compounds were non-cytotoxic. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15257770
- Volume :
- 35
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Nucleosides, Nucleotides & Nucleic Acids
- Publication Type :
- Academic Journal
- Accession number :
- 113740613
- Full Text :
- https://doi.org/10.1080/15257770.2015.1114131