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Effects of Re-Arterialization on Early Graft Function and Regeneration in the Rat Model of Heterotopic Auxiliary Liver Transplantation.
- Source :
-
European Surgical Research . 2000, Vol. 32 Issue 1, p11-17. 7p. 1 Diagram, 1 Chart, 3 Graphs. - Publication Year :
- 2000
-
Abstract
- In the rat model of heterotopic auxiliary liver transplantation, graft re-arterialization may influence the outcome of inter-liver competition. This was investigated in the current study using two transplanted groups with or without graft re-arterialization. Immediately after reperfusion, the re-arterialized grafts showed significantly higher bile flow rate and bilirubin excretion than the grafts without re-arterialization. DNA synthesis rate was also increased more drastically in the re-arterialized group following the transplantation. Without re-arterialization, the rats developed more pronounced cytolysis and cholestasis. Among the long-term survivors, all healthy re-arterialized grafts regenerated, whereas 5/6 non-re-arterialized grafts atrophied. These data demonstrate that the re-arterialization increases graft survival by improving early hepatic function, enhancing regenerative response and preventing post-transplant biliary complications in this rat model.Copyright © 2000 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0014312X
- Volume :
- 32
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- European Surgical Research
- Publication Type :
- Academic Journal
- Accession number :
- 11375427
- Full Text :
- https://doi.org/10.1159/000008735