Back to Search
Start Over
MicroRNA let-7g cooperates with interferon/ribavirin to repress hepatitis C virus replication.
- Source :
-
Journal of Molecular Medicine . Mar2016, Vol. 94 Issue 3, p311-320. 10p. - Publication Year :
- 2016
-
Abstract
- MicroRNAs (miRNA) have been implicated in HCV infection. The present study analyzed the effects of let-7g on HCV infection in vitro, in clinical tissue and serum samples. Here, we show that the expression of let-7g in serum and liver tissue is significantly higher in patients with sustained virologic response (SVR). We show that interferon (IFN)/ribavirin (RBV) induces let-7g expression through p38/AP-1 signaling. Overexpression of let-7g reduced HCV gene or core protein level and inhibited the HCV viral load. The let-7g and IFN/RBV have additively inhibitory effect on HCV replication. These data implicate let-7g as a new therapeutic drug to additively cooperate with IFN/RBV to repress HCV replication. Key messages: [ABSTRACT FROM AUTHOR]
- Subjects :
- *MICRORNA
*INTERFERONS
*RIBAVIRIN
*HEPATITIS C virus
*VIRAL replication
Subjects
Details
- Language :
- English
- ISSN :
- 09462716
- Volume :
- 94
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Molecular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 113929525
- Full Text :
- https://doi.org/10.1007/s00109-015-1348-1