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Prevalence of hypercalcemia of malignancy among cancer patients in the UK: analysis of the Clinical Practice Research Datalink database.
- Source :
-
Cancer Epidemiology . Dec 2015, Vol. 39 Issue 6, p901-907. 7p. - Publication Year :
- 2015
-
Abstract
- <bold>Background: </bold>The reported proportion of cancer patients who experience hypercalcemia of malignancy (HCM) ranges between 3% and 30%. HCM can be observed with any type of tumor and occurs most commonly in lung cancer, breast cancer and multiple myeloma. While HCM is a potentially fatal condition, the prevalence of HCM is not well defined.<bold>Methods: </bold>Using the United Kingdom Clinical Practice Research Datalink, we identified adult cancer patients with recorded corrected serum calcium (CSC). Hypercalcemic patients (CSC ≥ 10.8 mg/dL) were classified into 4 CSC levels. We estimated annual prevalence of HCM overall, stratified by cancer type, and in patients with stage IV cancer.<bold>Results: </bold>Among 37,442 cancer patients in 2003-2012 the prevalence of grade 1 HCM increased from 0.13% to 0.45% and the prevalence of HCM overall (grade 1 or higher) increased from 0.20% to 0.67% over the study period. Prevalence estimates varied across cancer type and were highest for lung cancer, multiple myeloma and patients with stage IV cancer.<bold>Conclusion: </bold>We provide the first systematic analysis using a UK population-based data source to estimate number of cancer patients affected with HCM by grade. The increase in HCM prevalence over the 10-year study period is likely due to the increased recording of laboratory values, particularly comparing more recent data to 2003. Our findings suggest that HCM in general is not a common condition. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18777821
- Volume :
- 39
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Cancer Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 113973314
- Full Text :
- https://doi.org/10.1016/j.canep.2015.10.012