Seco-Tremulanes from Cultures of the Basidiomycete Flavodon flavus BCC 17421.

A new seco-tremulane, 11,12-epoxy-5,6-secotremula-1,6(13)-dien-5,12-olide ( 1), was isolated together with the known compounds, conocenolides A ( 2) and B ( 3), tremulenediol A ( 4), tremulenolide A ( 5), and two lanostane triterpenoids, trametenolic acid B ( 6), and pinicolic acid A ( 7), from cultures of the basidiomycete Flavodon flavus BCC 17421. Interconversion of conocenolides A/B was demonstrated. Compound 1 exhibited weak cytotoxic activities, whereas tremulenediol A showed antiplasmodial activity ( IC50 8.6 μg/ml). Pinicolic acid A exhibited activity against herpes simplex virus type-1 ( IC50 15 μg/ml) as well as cytotoxic activities. [ABSTRACT FROM AUTHOR]