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Efficacy and safety of bovine activated factors IIa/VIIa/IXa/Xa in patients with active gastrointestinal bleeding: a proof of concept study.
- Source :
-
Endoscopy . 2016, Vol. 48 Issue 4, p380-384. 5p. - Publication Year :
- 2016
-
Abstract
- <bold>Background and Study Aims: </bold>Endoscopic treatment of active gastrointestinal bleeding often remains difficult, and considerable technical expertise is required. Our aim was to assess the efficacy and safety of endoscopic hemostasis with a liquid combination of bovine activated factors IIa/VIIa/IXa/Xa (SeraSeal).<bold>Methods: </bold>Patients with active gastrointestinal bleeding were prospectively included. In group A, 5 mL of bovine activated factors IIa/VIIa/IXa/Xa was topically applied via catheters to the bleeding site as initial hemostasis; group B received a similar application but as rescue therapy after failure of conventional endoscopic hemostasis.<bold>Results: </bold>In group A, bleeding was stopped by the agent in 15 /22 patients (68 %) and by conventional endoscopic hemostasis in 5 of the other 7, with coiling and surgery required for definitive hemostasis in 2. In group B, the addition of the agent definitively stopped bleeding in 13 /15 patients (87 %), with hemostasis in the remaining 2 achieved with fibrin glue. Rebleeding was observed in 1 patient.<bold>Conclusions: </bold>Our proof of concept study suggests that the use of bovine activated factors IIa/VIIa/IXa/Xa might be a safe and effective addition to current endoscopic hemostatic strategies, but further studies are necessary.ClinicalTrials.gov identifier: NCT02349490. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENDOSCOPY
*GASTROINTESTINAL hemorrhage
*HOMEOSTASIS
*FIBRIN
*HEMORRHAGE
*GASTROINTESTINAL hemorrhage diagnosis
*INTRANASAL medication
*ANIMAL experimentation
*BLOOD coagulation factors
*CALCIUM-binding proteins
*CATTLE
*COMBINATION drug therapy
*CLINICAL trials
*COMPARATIVE studies
*DOSE-effect relationship in pharmacology
*ENDOSCOPIC retrograde cholangiopancreatography
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*PROTEOLYTIC enzymes
*RESEARCH
*TIME
*EVALUATION research
*TREATMENT effectiveness
*ENDOSCOPIC hemostasis
Subjects
Details
- Language :
- English
- ISSN :
- 0013726X
- Volume :
- 48
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Endoscopy
- Publication Type :
- Academic Journal
- Accession number :
- 114136799
- Full Text :
- https://doi.org/10.1055/s-0034-1393312