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Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121.
- Source :
-
Molecules . Apr2016, Vol. 21 Issue 4, p371. 7p. 2 Diagrams, 2 Charts, 1 Graph. - Publication Year :
- 2016
-
Abstract
- Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectra. Compounds 1-3 were evaluated for in vitro growth inhibitory activities against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2), wherein compounds 1 and 3 exhibited considerable growth inhibitory effects, with IC50 values less than 10 μM. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MARINE fungi
*METABOLITES
*THIAZOLES
*CIRCULAR dichroism
*CELL lines
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 21
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 114166138
- Full Text :
- https://doi.org/10.3390/molecules21040371