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Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease.
- Source :
-
BBA: Molecular Basis of Disease . May2016, Vol. 1862 Issue 5, p992-1007. 16p. - Publication Year :
- 2016
-
Abstract
- Aging is the strongest known risk factor for Alzheimer's disease (AD). With the discovery of the mechanistic target of rapamycin (mTOR) as a critical pathway controlling the rate of aging in mice, molecules at the interface between the regulation of aging and the mechanisms of specific age-associated diseases can be identified. We will review emerging evidence that mTOR-dependent brain vascular dysfunction, a universal feature of aging, may be one of the mechanisms linking the regulation of the rate of aging to the pathogenesis of Alzheimer's disease. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09254439
- Volume :
- 1862
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- BBA: Molecular Basis of Disease
- Publication Type :
- Academic Journal
- Accession number :
- 114173779
- Full Text :
- https://doi.org/10.1016/j.bbadis.2015.11.010