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Systemic ocular antigen immunization leads only to a minor secondary immune response.
- Source :
-
Journal of Neuroimmunology . Apr2016, Vol. 293, p114-122. 9p. - Publication Year :
- 2016
-
Abstract
- The immunization with optic nerve homogenate antigen (ONA) or S100 induced retinal degeneration. Since many neurological diseases are reinforced or initiated by immune cells, leucocytes were analyzed. CD3 + T-cells in the retina increased slightly in ONA rats, but not in S100 treated retinas. No CD45R + B-cells and granulocytes could be detected in the retinas. At early stages, CD3 + cells, Iba1 + macrophages and granulocytes of the secondary lymphoid organs were not affected. Yet, the sole injection of pertussis toxin led to a shift to fewer CD45R + cells and more granulocytes in spleens. Later, splenic Iba1 + macrophages were increased in both groups. We conclude that the retinal infiltration of lymphocytes is not crucial for the degeneration process and rather an epiphenomenon. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 293
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 114202305
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2016.02.017