Back to Search Start Over

Epochs in the depressor/pressor balance of the renin-angiotensin system.

Authors :
Colafella, Katrina M. Mirabito
Hilliard, Lucinda M.
Denton, Kate M.
Source :
Clinical Science. May2016, Vol. 130 Issue 10, p761-771. 11p.
Publication Year :
2016

Abstract

The renin-angiotensin system (RAS) plays a commanding role in the regulation of extracellular fluid homoeostasis. Tigerstadt and Bergman first identified the RAS more than two centuries ago. By the 1980s a voyage of research and discovery into the mechanisms and actions of this system led to the development of drugs that block the RAS, which have become the mainstay for the treatment of cardiovascular and renal disease. In the last 25 years new components of the RAS have come to light, including the angiotensin type 2 receptor (AT2R) and the angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) [Ang(1-7)]/Mas receptor (MasR) axis. These have been shown to counter the classical actions of angiotensin II (AngII) at the predominant angiotensin type 1 receptor (AT1R). Our studies, and those of others, have demonstrated that targeting these depressor RAS pathways may be therapeutically beneficial. It is apparent that the evolution of both the pressor and depressor RAS pathways is distinct throughout life and that the depressor/pressor balance of the RAS vary between the sexes. These temporal patterns of expression suggest that therapies targeting the RAS could be optimized for discrete epochs in life. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01435221
Volume :
130
Issue :
10
Database :
Academic Search Index
Journal :
Clinical Science
Publication Type :
Academic Journal
Accession number :
114247173
Full Text :
https://doi.org/10.1042/CS20150939