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miR-429 functions as a tumor suppressor by targeting FSCN1 in gastric cancer cells.

Authors :
Min Zhang
Bing-bin Dong
Min Lu
Mei-juan Zheng
He Chen
Jing-zhen Ding
A-Man Xu
Yuan-hong Xu
Source :
OncoTargets & Therapy. Mar2016, Vol. 9, p1123-1133. 11p.
Publication Year :
2016

Abstract

It has been previously reported that the deregulation of microRNAs in gastric cancer (GC) was correlated with the progression and prognosis. miR-429, a member of the miR-200 family, was previously shown to play an important role in human carcinomas. Our study shows that miR-429 is significantly downregulated in GC tissues compared with matched nontumor tissues. Overexpression of miR-429 in GC cells suppressed cell proliferation. Fascin-1 (FSCN1) was identified as one of the targets of miR-429 and knockdown of FSCN1 mimics the function of miR-429 overexpression. In conclusion, miR-429 acts as a tumor suppressor by targeting FSCN1, suggesting that miR-429 and FSCN1 can both be potential therapeutic targets of GC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11786930
Volume :
9
Database :
Academic Search Index
Journal :
OncoTargets & Therapy
Publication Type :
Academic Journal
Accession number :
114305582
Full Text :
https://doi.org/10.2147/OTT.S91879