A Comparative Study of EEG Abnormalities among Subjects with Inter-Ictal Psychosis and Those with Schizophrenia.

Background: Electrophysiological investigation is an integral part in the management of neuropsychiatric disorders; but this is rare in developing countries including Nigeria. Objectives: The study aims to determine EEG abnormalities among subjects with inter-ictal psychosis in comparison to those with schizophrenia. Methods: A cross-sectional study of subjects with inter-ictal psychosis and those with schizophrenia. Each of the subjects that met the inclusion criteria had an awake EEG recording that lasted 45 minutes. Results: For PWEIP, the mean age was 23.9 (±13.8) years; and made up of 53 (53.0%) males; and for PWS, the mean age was 24.2 (±13.5) years; and there were 51 (51.0%) males. The EEG was normal in 53 (53.0%) of PWEIP and in 83 (83.0%) of PWS. EEG was abnormal in 47 (47.0%) of PWEIP, and 17 (17.0%) in those with PWS, and these were all 'epileptiform' activities, and the difference was statistically significant with X2=20.7 (Fisher's exact test), df=1 and p=0.00**. Conclusion: A number of subjects in our sample with inter-ictal psychosis and PWS had EEG epileptiform activities reflecting cerebral insults in early life. Thus, preventive measures such as good antenatal care are advocated to minimize the occurrence of these neuro-psychiatric disorders. [ABSTRACT FROM AUTHOR]