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Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma.
- Source :
-
Cancer Letters . Jun2016, Vol. 375 Issue 2, p331-339. 9p. - Publication Year :
- 2016
-
Abstract
- Microvesicles (MVs) secreted from cells have been found to mediate signal transduction between cells. In the tumor microenvironment, VEGF released from cancer cells plays a key role in promoting tumor angiogenesis. In this study, we characterized the inhibitory effect of MV-delivered miR-29a/c on angiogenesis and tumor growth in gastric cancer (GC). We found that the downregulation of miR-29a/c increases VEGF expression and release in GC cells, promoting the growth of vascular cells. By simulating the tumor microenvironment, the MV-delivered miR-29a/c significantly suppresses VEGF expression in GC cells, inhibiting vascular cell growth, metastasis, and tube formation. We also used a tumor implantation mouse model to show that secreted MVs containing overexpressed miR-29a/c significantly reduced the growth rate of the vasculature and tumors in vivo. To conclude, our results contribute to a novel anti-cancer strategy using miRNA-containing MVs to control tumor cell growth by blocking angiogenesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MICRORNA
*NEOVASCULARIZATION
*STOMACH cancer patients
*VESICLES (Cytology)
*CELLULAR signal transduction
*CANCER chemotherapy
*ANIMAL experimentation
*CANCER
*CELL lines
*CELL membranes
*CELL physiology
*DRUG delivery systems
*GENES
*MICE
*RNA
*STOMACH tumors
*VASCULAR endothelial growth factors
*PATHOLOGIC neovascularization
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 375
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 114483101
- Full Text :
- https://doi.org/10.1016/j.canlet.2016.03.026