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Design, Synthesis and Biological Evaluation of 2-Phenoxy-N-Phenylacetamides as Novel Anticancer Agents.
- Source :
-
Pharmaceutical Chemistry Journal . Mar2016, Vol. 49 Issue 12, p798-803. 6p. - Publication Year :
- 2016
-
Abstract
- A series of 2-phenoxy-N-phenylacetamides were designed and synthesized with a view to develop novel anticancer agents. All compounds were prepared with varied substitutions in the phenyl ring of aniline and evaluated for their anticancer activity. The majority of them displayed a moderate degree of cytotoxicity against several human cancer cell lines. Six compounds displayed potent cell growth inhibitory activity with IC values below 20 μM. Two compounds ( TC-5 and TC-14) exhibited the most pronounced antiproliferative activity equivalent to or higher than that of positive control. The structure - activity relationship of these anticancer agents has been reviewed. The results indicate that incorporation of halogen into the benzene ring is beneficial for anticancer activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0091150X
- Volume :
- 49
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Pharmaceutical Chemistry Journal
- Publication Type :
- Academic Journal
- Accession number :
- 114605335
- Full Text :
- https://doi.org/10.1007/s11094-016-1374-5