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Decreased hepatic contents of coenzyme A molecular species in mice after subchronic mild social defeat stress.
- Source :
-
Stress: The International Journal on the Biology of Stress . Mar2016, Vol. 19 Issue 2, p192-197. 6p. - Publication Year :
- 2016
-
Abstract
- Social stress may precipitate psychiatric disorders such as depression, which is related to the occurrence of the metabolic syndrome, including obesity and type 2 diabetes. We have evaluated the effects of social stress on central and peripheral metabolism using a model of depression in mice. In the present study, we focused on coenzyme A (CoA) molecular species [i.e. non-esterified CoA (CoASH), acetyl-CoA and malonyl-CoA] which play important roles in numerous metabolic pathways, and we analyzed changes in expression of these molecules in the hypothalamus and liver of adult male mice (C57BL/6J) subjected to 10 days of subchronic mild social defeat stress (sCSDS) with ICR mice as aggressors. Mice (nā=ā12) exposed to showed hyperphagia- and polydipsia-like symptoms and increased body weight gain compared with control mice which were not affected by exposure to ICR mice (nā=ā12). To elucidate the underlying metabolic features in the sCSDS model, acetyl-CoA, malonyl-CoA and CoASH tissue levels were analyzed using the acyl-CoA cycling method. The levels of hypothalamic malonyl-CoA, which decreases feeding behavior, were not influenced by sCSDS. However, sCSDS reduced levels of acetyl-CoA, malonyl-CoA and total CoA (sum of the three CoA molecular species) in the liver. Hence, hyperphagia-like symptoms in sCSDS mice evidently occurred independently of hypothalamic malonyl-CoA, but might consequently lead to down-regulation of hepatic CoA via altered expression of nudix hydrolase 7. Future studies should investigate the molecular mechanism(s) underlying the down-regulation of liver CoA pools in sCSDS mice. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *COENZYME A
*HYPOTHALAMUS
*LIVER
*PSYCHOLOGICAL stress research
Subjects
Details
- Language :
- English
- ISSN :
- 10253890
- Volume :
- 19
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Stress: The International Journal on the Biology of Stress
- Publication Type :
- Academic Journal
- Accession number :
- 114607673
- Full Text :
- https://doi.org/10.3109/10253890.2015.1137558