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The IL6R gene polymorphisms are associated with sIL-6R, IgE and lung function in Chinese patients with asthma.
- Source :
-
Gene . Jul2016, Vol. 585 Issue 1, p51-57. 7p. - Publication Year :
- 2016
-
Abstract
- Background: sIL-6R is involved in a variety of inflammatory diseases. The present study analyzed the potential associations between two IL6R gene polymorphisms (rs2228145 and rs12083537) and asthma in a Han Chinese population. Methods: A cohort of 394 patients and 395 healthy controls were genotyped to detect the two polymorphisms using SNaPshot. In 66 asthma patients and 49 controls, peripheral eosinophil and serum immunoglobulin E (IgE) levels were determined using a routine blood test, and sIL-6R levels were measured by ELISA. Results: No statistically significant differences were detected between the patients and controls in the distribution of the two independent IL6R polymorphisms (p > 0.05). However, rs2228145 C and rs12083537 G were significantly associated with decreased lung function in patients with asthma; the rs2228145 A–C variant was also associated with increased sIL-6R and IgE levels. In addition, sIL-6R levels were positively associated with IgE and inversely associated with lung function in patients with asthma. Conclusions: Our results provide evidence that rs2228145 C and rs12083537 G are associated with poor lung function in patients with asthma. Furthermore, the rs2228145 A–C variant is associated with levels of sIL-6R and IgE. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03781119
- Volume :
- 585
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Gene
- Publication Type :
- Academic Journal
- Accession number :
- 114630069
- Full Text :
- https://doi.org/10.1016/j.gene.2016.03.026