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Correlation of first-trimester serum levels of pregnancy-associated plasma protein A with small-for-gestational-age neonates and preterm births.
- Source :
-
International Journal of Gynecology & Obstetrics . May2016, Vol. 133 Issue 2, p159-163. 5p. - Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>To analyze the relationship between first-trimester levels of pregnancy-associated plasma protein A (PAPP-A) and small-for-gestational-age (SGA) neonates and preterm births, and to assess predictive utility for these events.<bold>Methods: </bold>A prospective study was conducted among women undergoing first-trimester screening between January 1, 2012, and December 31, 2013, at two centers in Pune, India. Serum PAPP-A levels, pregnancy course, and outcome were assessed.<bold>Results: </bold>Overall, 1474 women were included. An association was found between the lowest quintile of PAPP-A levels (<0.4 multiples of median) for both SGA (<10th centile; 20.9% of cases in this PAPP-A quintile) and preterm birth (<37weeks; 15.8%). Women in the lowest quintile of PAPP-A concentration had a significantly increased risk of SGA (<10th centile) than did those with higher concentrations (adjusted odds ratio 2.92, 95% confidence interval 2.00-4.27). Their risk of preterm birth (<37weeks) was also increased (adjusted odds ratio 1.84, 95% confidence interval 1.25-2.72). The predictive sensitivities of the lowest quintile of PAPP-A were 35.85% for SGA (<10th centile) and 27.92% for preterm birth (<37weeks).<bold>Conclusion: </bold>Low levels of PAPP-A were associated with SGA and preterm births; however, poor predictive sensitivity could restrict clinical utility of this marker when used alone. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FIRST trimester of pregnancy
*BLOOD proteins
*BLOOD serum analysis
*GESTATIONAL age
*NEWBORN infant care
*PREMATURE labor
*BIRTH size
*CHORIONIC gonadotropins
*FETAL growth retardation
*PREMATURE infants
*LONGITUDINAL method
*EVALUATION of medical care
*PREGNANCY
*PREGNANCY proteins
*PRENATAL diagnosis
*LOGISTIC regression analysis
Subjects
Details
- Language :
- English
- ISSN :
- 00207292
- Volume :
- 133
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- International Journal of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 114673950
- Full Text :
- https://doi.org/10.1016/j.ijgo.2015.09.022