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Cu(l)-Catalyzed Asymmetric Multicomponent Cascade Inverse Electron-Demand Aza-Diels--Alder/Nucleophilic Addition/Ring-Opening Reaction Involving 2-Methoxyfurans as Efficient Dienophiles.
- Source :
-
Journal of the American Chemical Society . 3/30/2016, Vol. 138 Issue 12, p3998-4001. 4p. - Publication Year :
- 2016
-
Abstract
- An unprecedented multicomponent cascade asymmetric inverse-electron-demand Diels-Alder/nucleophilic addition/ring-opening reaction involving 2-methoxyfurans as efficient dienophiles was successfully developed with Cu(I)/tBu-Box complex as the catalyst. A diverse array of tetrahydropyridazines containing unexpectedly stable γ-hydroxyl ester moiety was obtained in generally good yield with exclusive regioselectivity and excellent stereoselectivity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 138
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 114700218
- Full Text :
- https://doi.org/10.1021/jacs.6b01008