Cu(l)-Catalyzed Asymmetric Multicomponent Cascade Inverse Electron-Demand Aza-Diels--Alder/Nucleophilic Addition/Ring-Opening Reaction Involving 2-Methoxyfurans as Efficient Dienophiles.

An unprecedented multicomponent cascade asymmetric inverse-electron-demand Diels-Alder/nucleophilic addition/ring-opening reaction involving 2-methoxyfurans as efficient dienophiles was successfully developed with Cu(I)/tBu-Box complex as the catalyst. A diverse array of tetrahydropyridazines containing unexpectedly stable γ-hydroxyl ester moiety was obtained in generally good yield with exclusive regioselectivity and excellent stereoselectivity. [ABSTRACT FROM AUTHOR]