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Combination Emtricitabine and Tenofovir Disoproxil Fumarate Prevents Vaginal Simian/Human Immunodeficiency Virus Infection in Macaques Harboring Chlamydia trachomatis and Trichomonas vaginalis.
- Source :
-
Journal of Infectious Diseases . 5/15/2016, Vol. 213 Issue 10, p1541-1545. 5p. - Publication Year :
- 2016
-
Abstract
- Genital inflammation associated with sexually transmitted infections increases susceptibility to human immunodeficiency virus (HIV), but it is unclear whether the increased risk can reduce the efficacy of pre-exposure prophylaxis (PrEP). We investigated whether coinfection of macaques with Chlamydia trachomatis and Trichomonas vaginalis decreases the prophylactic efficacy of oral emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF). Macaques were exposed to simian/human immunodeficiency virus (SHIV) vaginally each week for up to 16 weeks and received placebo or FTC/TDF pericoitally. All animals in the placebo group were infected with SHIV, while 4 of 6 PrEP recipients remained uninfected (P= .03). Oral FTC/TDF maintains efficacy in a macaque model of sexually transmitted coinfection, although the infection of 2 macaques signals a modest loss of PrEP activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TENOFOVIR
*BISOPROLOL
*MEDICAL microbiology
*HUMAN microbiota
*MEDICAL bacteriology
*HIV prevention
*ANTI-HIV agents
*RNA virus infections
*ANIMAL experimentation
*BIOLOGICAL models
*CHLAMYDIA infections
*CHLAMYDIA trachomatis
*TRICHOMONAS vaginalis
*PREVENTIVE health services
*PRIMATES
*RESEARCH funding
*VAGINA
*MIXED infections
*DISEASE complications
*PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 213
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 114708703
- Full Text :
- https://doi.org/10.1093/infdis/jiw002