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A General Method for Aminoquinoline-Directed, Copper-Catalyzed sp2 C-H Bond Amination.
- Source :
-
Journal of the American Chemical Society . 4/6/2016, Vol. 138 Issue 13, p4601-4607. 7p. - Publication Year :
- 2016
-
Abstract
- An operationally simple and general method for copper-catalyzed, aminoquinoline-assisted amination of βC(sp2)-H bonds of benzoic acid derivatives is reported. The reaction employs Cu(OAc)2 or (Cu0H)2C03 catalysts, an amine coupling partner, and oxygen from air as a terminal oxidant. Exceptionally high generality with respect to amine coupling partners is observed. Specifically, primary and secondary aliphatic and aromatic amines, heterocycles, such as indoles, pyrazole, and carbazole, sulfonamides, as well as electron-deficient aromatic and heteroaromatic amines are competent coupling components. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINATION
*COPPER research
*CATALYSIS research
*QUINOLINE
*BENZOIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 138
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 114714952
- Full Text :
- https://doi.org/10.1021/jacs.6b01117