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Expression of Class I and Class II major histocompatibility complex antigens on oral mucosal epithelium.
- Source :
-
Journal of Oral Pathology . Mar87, Vol. 16 Issue 3, p153-157. 5p. - Publication Year :
- 1987
-
Abstract
- The expression of the Class I and Class II major histocompatibility antigens on oral mucosa was investigated using type-specific monoclonal antibodies. Class I antigen expression varied between various sites and in uncomplicated inflammatory responses appeared to be suppressed. HLA-DR antigen expression was only present on epithelial cells in the presence of extraneous immunocompetent cells. Oral mucosa did not express HLA-DQ antigens. The expression of Class I and Class II antigens varied between disease states exhibiting proliferative or destructive tissue responses. The pattern of Class I and Class II antigen expression is consistent with either MHC-restricted cellular interactions and subsequent destruction of epithelial cells or a protective role in non-destructive conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HISTOCOMPATIBILITY antigens
*ORAL mucosa
*ANTIGENS
*EPITHELIUM
Subjects
Details
- Language :
- English
- ISSN :
- 03009777
- Volume :
- 16
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Oral Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 11478539
- Full Text :
- https://doi.org/10.1111/j.1600-0714.1987.tb01484.x