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The role of diffusion-weighted imaging in the detection of hepatic metastases from colorectal cancer: A comparison with unenhanced and Gd-EOB-DTPA enhanced MRI.
- Source :
-
European Journal of Radiology . May2016, Vol. 85 Issue 5, p1027-1034. 8p. - Publication Year :
- 2016
-
Abstract
- <bold>Objectives: </bold>To compare the role of DWI vs. gadoxetic-acid-disodium enhanced MRI in the detection of colorectal hepatic metastases.<bold>Methods: </bold>Fifty-four patients with 115 hepatic metastases were included in this retrospective study, approved by the Ethical Board. All patients underwent intraoperative-ultrasound and surgical resection within two weeks after MRI. Images were grouped in 4 sets, which were analyzed by two radiologists in different sessions: unenhanced T1-T2w (set A), set A plus DWI (set B), set A plus gadoxetic-acid-disodium (set C), set A plus DWI plus gadoxetic-acid-disodium (set D). For each set, metastases presence/size/site was reported. Interobserver agreement and statistical significance were assessed by Cohen's kappa and Mc-Nemar's test, respectively.<bold>Results: </bold>Readers' agreement was always very good (k>0.80). Mean sensitivity values were 84.3/92.1/95.6/97.3% for set A/B/C/D, respectively. Mean specificity, positive predicted, negative predicted, and accuracy values strongly and progressively increased in the various set too: from 62.5% (set A) to 85.0% as for specificity, from 92.8% to 97.3% as for positive predicted value, from 41.0% to 85.1% as for negative predicted value, and from 81.1% to 95.5% as for accuracy. For each reader from set A to D, the number of false negatives progressively decreases.<bold>Conclusions: </bold>For both readers, DWI improved all statistical parameters in the unenhanced examinations, as for nodules either smaller or greater than 1cm, while in the EOB-enhanced examinations DWI prevalently increased specificity/negative predictive value. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COLON cancer diagnosis
*LIVER metastasis
*DIFFUSION magnetic resonance imaging
*SURGICAL excision
*DIETHYLENETRIAMINEPENTAACETIC acid
*MAGNETIC resonance imaging of cancer
*DIAGNOSIS
*COLON tumors
*COMPARATIVE studies
*LIVER tumors
*MAGNETIC resonance imaging
*RESEARCH methodology
*MEDICAL cooperation
*IMAGING phantoms
*RESEARCH
*EVALUATION research
*CONTRAST media
*RETROSPECTIVE studies
RECTUM tumors
Subjects
Details
- Language :
- English
- ISSN :
- 0720048X
- Volume :
- 85
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Journal of Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 114874480
- Full Text :
- https://doi.org/10.1016/j.ejrad.2016.02.011