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History of chromosome rearrangements reflects the spatial organization of yeast chromosomes.

Authors :
Khrameeva, Ekaterina E.
Fudenberg, Geoffrey
Gelfand, Mikhail S.
Mirny, Leonid A.
Source :
Journal of Bioinformatics & Computational Biology. Apr2016, Vol. 14 Issue 2, p-1. 12p.
Publication Year :
2016

Abstract

Three-dimensional (3D) organization of genomes affects critical cellular processes such as transcription, replication, and deoxyribo nucleic acid (DNA) repair. While previous studies have investigated the natural role, the 3D organization plays in limiting a possible set of genomic rearrangements following DNA repair, the influence of specific organizational principles on this process, particularly over longer evolutionary time scales, remains relatively unexplored. In budding yeast S.cerevisiae, chromosomes are organized into a Rabl-like configuration, with clustered centromeres and telomeres tethered to the nuclear periphery. Hi-C data for S.cerevisiae show that a consequence of this Rabl-like organization is that regions equally distant from centromeres are more frequently in contact with each other, between arms of both the same and different chromosomes. Here, we detect rearrangement events in Saccharomyces species using an automatic approach, and observe increased rearrangement frequency between regions with higher contact frequencies. Together, our results underscore how specific principles of 3D chromosomal organization can influence evolutionary events. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02197200
Volume :
14
Issue :
2
Database :
Academic Search Index
Journal :
Journal of Bioinformatics & Computational Biology
Publication Type :
Academic Journal
Accession number :
114885377
Full Text :
https://doi.org/10.1142/S021972001641002X