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CD4 down regulation and raft dissociation by the non-depleting YTS177 antibody hinder murine T helper cell activities.
- Source :
-
Biochemical & Biophysical Research Communications . May2016, Vol. 473 Issue 4, p973-979. 7p. - Publication Year :
- 2016
-
Abstract
- Non-depleting YTS177 anti-CD4 monoclonal antibody (MoAb) has been reported to lead to antigen-specific immunotolerance in allograft transplantation and autoimmune diabetes, as well as possibly to inhibition of allergic inflammation in mice. However, the molecular mechanisms underlying hyporesponsive T cell responses induced by YTS177 MoAb remain elusive. Herein, we demonstrate that the YTS177 MoAb increases the levels of anergy factors p27 kip1 and Cbl-b, inhibits IL-2 production, and impairs calcium mobilization in activated T cells in vitro . YTS177 MoAb suppresses OVA-driven proliferation of DO11.10 CD4 + T cells in vivo as well. Mechanistically, YTS177 MoAb induces tolerance by causing CD4 down-regulation through clathrin-dependent and raft dissociation. The results obtained in this study lead us to propose novel protective or curative approaches to CD4 T cell-mediated diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 473
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 114987019
- Full Text :
- https://doi.org/10.1016/j.bbrc.2016.04.001