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A General Copper-Catalyzed Vinylic Halogen Exchange Reaction.
- Source :
-
Organic Letters . Apr2016, Vol. 18 Issue 8, p1904-1907. 4p. - Publication Year :
- 2016
-
Abstract
- An efficient and general system for the halogen exchange reaction in alkenyl halides has been developed. Upon reaction with catalytic amounts of copper iodide and trans-N,N'-dimethylcyclohexane-1,2-diamine in the presence of tetramethylammonium chloride or bromide, a wide range of easily accessible alkenyl iodides can be smoothly transformed to their far less available chlorinated and brominated derivatives in excellent yields and with full retention of the double bond geometry. This reaction also enables the chlorination of bromoalkenes and could be extended to the use of gem-dibromoalkenes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COPPER catalysts
*HALOGENS
*EXCHANGE reactions
*ALKENYLATION
*CUPROUS iodide
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 18
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 115158387
- Full Text :
- https://doi.org/10.1021/acs.orglett.6b00678