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Recent developments in the synthesis and utilization of chiral β-aminophosphine derivatives as catalysts or ligands.
- Source :
-
Chemical Society Reviews . 3/21/2016, Vol. 45 Issue 6, p1657-1677. 21p. - Publication Year :
- 2016
-
Abstract
- In the last few years, the research area of chiral β-aminophosphines capable of promoting a wide range of diverse organic transformations has attracted more attention. Their derivatives constitute attractive reagents towards this end, due to their stability, low toxicity and ease of handling. These novel β-aminophosphine derivatives are potentially useful as organocatalysts and ligands in metal-catalysed reactions. In particular, chiral β-aminophosphines have recently emerged as powerful phosphine catalysts in asymmetric synthesis and catalysis. The asymmetric transformations to which metal complexes of these ligands have been applied include palladium-catalysed allylic substitutions and copper-catalysed 1,4-additions to enones among others. This review summarizes the most significant developments in the area of synthesis and application of chiral β-aminophosphine derivatives, providing a detailed overview of the current state of the art and including future aspects. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03060012
- Volume :
- 45
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Chemical Society Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 115165964
- Full Text :
- https://doi.org/10.1039/c5cs00469a