Back to Search Start Over

Surgical treatment of early knee osteoarthritis with a cell-free osteochondral scaffold: results at 24 months of follow-up.

Authors :
Di Martino, Alessandro
Kon, Elizaveta
Perdisa, Francesco
Sessa, Andrea
Filardo, Giuseppe
Neri, Maria Pia
Bragonzoni, Laura
Marcacci, Maurilio
Source :
Injury. Dec2015 Supplement 7, Vol. 46, pS33-S38. 6p.
Publication Year :
2015

Abstract

<bold>Purpose: </bold>"Early Osteoarthritis (EOA)" has been defined combining clinical, imaging and surgical parameters, with the aim to identify patients in early degenerative phases, who might benefit from the use of available regenerative procedures. Aim of this first clinical trial is to prospectively evaluate the results obtained in a group of patients meeting the inclusion criteria of "EOA" as proposed by the ESSKA Cartilage Committee, and surgically treated with the implantation of a multi-phasic osteochondral scaffold.<bold>Methods: </bold>23 patients were prospectively evaluated at 12 and 24 months of follow-up. Etiology of the chondral or osteochondral defect was rated as microtraumatic or degenerative in 18 cases, and traumatic in 5 cases. Patients included were complaining of clinical symptoms like knee pain and affected by chondral and osteochondral lesions located at the femoral condyles or trochlea and MRI findings demonstrating articular cartilage degeneration and/or meniscal degeneration and/or subchondral bone marrow lesions.<bold>Results: </bold>All patients increased significantly in any clinical score adopted. The IKDC subjective score increased from 42.8 ± 13.8 at basal evaluation to 74.3 ± 17.4 at 12 months' (p < 0.0005), being stable (74.9 ± 20.4) up to the final follow-up of 24 months. Tegner score showed a statistically significant improvement in sports activity from 3.3 ± 2.7 pre-operative to 4.6 ± 2.2 at 12 months (p < 0.005), with a slight improvement to the final evaluation (4.7 ± 2.1; n.s.). However, the activity level was significantly lower than the pre-injury one (6.1 ± 2.6; p = 0.004). A significant difference was shown between patients younger versus older than 40 years, with younger patients had better clinical improvement (76.0 ± 18.6 vs 45.1 ± 38.8 respectively, p = 0.037).<bold>Conclusions: </bold>The implantation of a multi-phasic osteochondral scaffold represents a good option after failure of conservative management for Early OA patients, where younger age represent an important factor for a better outcome. Longer follow-up is needed to evaluate the benefit over time.<bold>Level Of Evidence: </bold>IV, case series. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00201383
Volume :
46
Database :
Academic Search Index
Journal :
Injury
Publication Type :
Academic Journal
Accession number :
115177466
Full Text :
https://doi.org/10.1016/S0020-1383(15)30052-8