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PET imaging of prostate cancer with F-Al-NODA-MATBBN.
- Source :
-
Journal of Radioanalytical & Nuclear Chemistry . Jun2016, Vol. 308 Issue 3, p905-911. 7p. 2 Diagrams, 1 Chart, 3 Graphs. - Publication Year :
- 2016
-
Abstract
- We explored the application of new bifunctional chelating agent p-SCN-NODA by conjugating to GRPR targeting peptide, MATBBN. p-SCN-NODA can increase the labeling yield to 68.3 ± 1.8 %. F-Al-NODA-MATBBN can be produced within 25 min with a radiochemical purity of more than 98 %. At 30 min post-injection, the tumor uptake for F-Al-NODA-MATBBN was 3.23 ± 0.23 % ID/g. Biodistribution studies revealed that F-Al-NODA-MATBBN was excreted mainly through the kidneys. GRPR-binding specificity was also demonstrated by reduced tumor uptake of F-Al-NODA-MATBBN after co-injection with excess unlabeled MATBBN peptide at 1 h post-injection. It suggests that F-Al-NODA-MATBBN may be a potential PET tracer candidate for monitoring prostate cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02365731
- Volume :
- 308
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Radioanalytical & Nuclear Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 115231223
- Full Text :
- https://doi.org/10.1007/s10967-015-4577-4