Nonenzymatic Electrochemical Biosensor Based on Novel Hydrophilic Ferrocene-terminated Hyperbranched Polymer and its Application in Glucose Detection.

We designed a novel water soluble topological structure polymer-ferrocene- terminated hyperbranched polyurethane (HPU-Fc) with good water solubility. The redox behaviors and the electrochemical kinetics parameters of HPU-Fcs were explored by cyclic voltammetry (CV) according to electrochemical principle. The topological structure polymer was applied for the design and engineering of non-enzymatic glucose sensor. The designed sensor showed good response to glucose concentration with good stability, favorable accuracy and high selectivity. The electrode was also used to detect glucose in blood samples, and the glucose contents detected by the electrode were in good agreement with those from the hospital where a common automatic biochemical analyzer (HF240-300) was used. This finding makes HPU-Fc a promising biosensor for directly sensing glucose. [ABSTRACT FROM AUTHOR]