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Interactions between maternal killer cell immunoglobulin receptor genes and foetal HLA ligand genes contribute to type 1 diabetes susceptibility in Han Chinese.
- Source :
-
International Journal of Immunogenetics . Jun2016, Vol. 43 Issue 3, p125-130. 6p. - Publication Year :
- 2016
-
Abstract
- In this study, we aimed to test the hypothesis that KIR haplotypes (that interact with HLA class I molecules) are associated with susceptibility in patients with T1 DM in utero through maternal-foetal interaction of KIR and their HLA class I ligands in Han Chinese population. We determined the KIR genes and KIR/ligand gene combination frequencies in 59 Han Chinese children with T1D and their mothers and compared it with 159 healthy control children and their mothers. The absence of KIR-2 DS1 in the mother and the presence of HLA-C2 ligand in the child were negatively associated with type 1 diabetes in the child. Our results indicate that maternal KIR genes and their interaction with foetal HLA-C2 may contribute to the risk of type 1 diabetes among Han Chinese children. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17443121
- Volume :
- 43
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Journal of Immunogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 115268241
- Full Text :
- https://doi.org/10.1111/iji.12257