Front Cover Picture: Catalytic One-Pot Oxetane to Carbamate Conversions: Formal Synthesis of Drug Relevant Molecules (Adv. Synth. Catal. 10/2016).

The front cover picture, provided by Arjan Kleij and co ‐ workers, illustrates oxetane ‐ based carbamates: oxetane ‐ based carbamate scaffolds are formed using an efficient aluminium catalyst. The process combines three reagents (CO2, oxetanes and amines) in a one ‐ pot approach towards a wide diversity of carbamate structures. The methodology has been applied in the formal synthesis of drug ‐ relevant molecules such as Carisoprodol and the mono ‐ carbamate of Felbatol showing the utility of the new catalytic procedure. The work also illustrates the potential of oxetanes as versatile reagents in pharma ‐ organic synthesis. Details can be found in the full paper on pages 1602 – 1607 (W. Guo, V. Laserna, J. Rintjema, A. W. Kleij, Adv. Synth. Catal.­ 2016, 358, 1602 – 1607; DOI: 10.1002/adsc.201500895). [ABSTRACT FROM AUTHOR]