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Dietary fatty acids and risk of hepatocellular carcinoma in the Singapore Chinese health study.

Authors :
Koh, Woon ‐ Puay
Dan, Yock Young
Goh, George Boon ‐ Bee
Jin, Aizhen
Wang, Renwei
Yuan, Jian ‐ Min
Source :
Liver International. Jun2016, Vol. 36 Issue 6, p893-901. 9p. 5 Charts.
Publication Year :
2016

Abstract

Background & Aim Lipidomic signature of lipid metabolism suggests that omega-6 polyunsaturated fatty acids ( PUFA) may play a role in oncogenesis of hepatocellular carcinoma ( HCC). Hence, we examined the association between dietary fatty acids and risk of HCC. Methods We used data from the Singapore Chinese Health Study, a population-based prospective cohort of 63 257 Chinese men and women aged 45-74 years enrolled between 1993 and 1998. Information on current diet assessed via a validated semi-quantitative food frequency questionnaire, medical history and lifestyle factors were obtained through in-person interview, and incidence of HCC recorded through 31 Dec 2010. We also examined the association between dietary fatty acids and HCC risk using a case-control set of 92 cases and 274 controls with available serological biomarkers of chronic infections with hepatitis B virus ( HBV) and hepatitis C virus ( HCV) nested within this cohort. Results Among the dietary fat components examined, which included saturated, monounsaturated, omega-3 and omega-6 PUFA, only omega-6 PUFA intake displayed a dose-dependent, positive association with HCC risk (p for trend = 0.02). Compared to the lowest quartile, the hazard ratio for the highest quartile intake was 1.49 [(95% confidence interval ( CI):1.08-2.07)]. In the nested case-control study, only among individuals negative for serology markers of chronic infection with HBV or HCV, those who consumed above median levels of dietary omega-6 PUFA had increased HCC risk (odds ratio = 4.36, 95% CI = 1.59-11.94) compared to those with lower intake. Conclusion Dietary omega-6 PUFA may be implicated in the risk of non-viral hepatitis related HCC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14783223
Volume :
36
Issue :
6
Database :
Academic Search Index
Journal :
Liver International
Publication Type :
Academic Journal
Accession number :
115350238
Full Text :
https://doi.org/10.1111/liv.12978