Back to Search
Start Over
A Comparative Ancillary Ligand Survey in Palladium-Catalyzed C-O Cross-Coupling of Primary and Secondary Aliphatic Alcohols.
- Source :
-
European Journal of Organic Chemistry . May2016, Vol. 2016 Issue 14, p2444-2449. 6p. - Publication Year :
- 2016
-
Abstract
- The utility of RockPhos, Ad-BippyPhos, JosiPhos (CyPF- tBu), and Mor-DalPhos in palladium-catalyzed C-O cross-coupling reactions involving aliphatic alcohols and (hetero)aryl halides under analogous conditions was examined, both at room temperature and at elevated temperature (90 °C). In general, the RockPhos-based catalyst system proved superior, especially at room temperature, but catalysts based on the other ligands examined also proved effective across a range of C-O cross-couplings, in some cases providing better catalytic performance than RockPhos. New reactivity was established in terms of the scope of room temperature reactions. Proof-of-principle examples of such cross-couplings involving aryl mesylates were also demonstrated. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2016
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 115376244
- Full Text :
- https://doi.org/10.1002/ejoc.201600198