New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against α-glucosidase and PTP1B.

Nine new sesquiterpenoids, clitocybulol derivatives, clitocybulols G–O ( 1–9 ) and three known sesquiterpenoids, clitocybulols C–E ( 10 − 12 ), were isolated from the solid culture of the edible fungus Pleurotus cystidiosus . The structures of compounds 1–12 were determined by spectroscopic methods. The absolute configurations of compounds 1–9 were assigned via the circular dichroism (CD) data analysis. Compounds 1 , 6 and 10 showed moderate inhibitory activity against protein tyrosine phosphatase-1B (PTP1B) with IC 50 values of 49.5, 38.1 and 36.0 μM, respectively. [ABSTRACT FROM AUTHOR]