Back to Search
Start Over
Mathematical Modelling of Venom Immunotherapy.
- Source :
-
Journal of Theoretical Medicine . Jun2002, Vol. 4 Issue 2, p119-132. 14p. - Publication Year :
- 2002
-
Abstract
- Allergic hypersensitivity of type I for hymenoptera venoms is the most frequent reason for acute IgE-mediated anaphylactic reactions. The subcutaneous injection of increasing doses of purified allergen followed by long-term administration of an adequate maintenance dose over a period of 3-5 years called venom immunotherapy (VIT) has been proven to be a very effective treatment achieving protection in about 96% of allergic patients. Even though the principle of hyposensitisation has been introduced already 90 years ago, the underlying immunoregulatory mechanisms of VIT remain poorly understood. Recent studies suggest a shift in cytokine production from a Th2 to a Th1 cytokine profile during therapy. In this paper, a mathematical model for T-cell regulation and a model for mast cell/basophil desensitisation are presented and analysed to explain the mechanism of conventional rush and ultra-rush VIT. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*MAST cells
*BASOPHILS
*IMMUNOTHERAPY
*IMMUNOGLOBULIN E
*MATHEMATICAL models
Subjects
Details
- Language :
- English
- ISSN :
- 10273662
- Volume :
- 4
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Theoretical Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 11550547
- Full Text :
- https://doi.org/10.1080/10273660290022172