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Fulminant adenovirus hepatitis after hematopoietic stem cell transplant: Retrospective real-time PCR analysis for adenovirus DNA in two cases.
- Source :
-
Journal of Infection & Chemotherapy (Elsevier Inc.) . Dec2015, Vol. 21 Issue 12, p857-863. 7p. - Publication Year :
- 2015
-
Abstract
- Background Viral infection is one of the major causes of mortality in patients undergoing hematopoietic stem cell transplant (HSCT). Systemic infection of adenovirus (AdV) has emerged as a not uncommon viral infection with significant morbidity and mortality as with cytomegalovirus and Epstein–Barr virus infection. Routine surveillance for these viruses has become a clinical practice and subsequent preemptive therapy improves patients' outcomes; however, the effectiveness of preemptive therapy for AdV has not been fully investigated in patients with a lethal form of AdV infection. Methods Sequential AdV loads were retrospectively analyzed in children with fulminant AdV hepatitis after HSCT. Results The AdV DNA became detectable (1 × 10 4 copies/mL) as early as 2 weeks after HSCT. These levels reached >1 × 10 8 copies/mL at the onset of fulminant hepatitis. However, we determined that γ-glutamyltransferase levels were elevated to >100 IU/L at least 2 weeks before the diagnosis of hepatitis. Conclusions Our observation raises the possibility that elevated γ-glutamyltransferase could be a sentinel marker for AdV hepatitis, which prompts elaborated monitoring of AdV load and targeted treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1341321X
- Volume :
- 21
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Infection & Chemotherapy (Elsevier Inc.)
- Publication Type :
- Academic Journal
- Accession number :
- 115551892
- Full Text :
- https://doi.org/10.1016/j.jiac.2015.08.018