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Bronchopulmonary infection–colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study.
- Source :
-
Journal of Cystic Fibrosis . May2016, Vol. 15 Issue 3, p357-365. 9p. - Publication Year :
- 2016
-
Abstract
- Background Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented. Methods 24 CF-Units for adult (n = 12) and pediatric (n = 12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed. Results 341 patients [mean (SD) age 21 (11) years, 180 ≥ 18 years, mean (SD) FEV 1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV 1 (p < 0.001 and p = 0.003, respectively). Conclusions The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15691993
- Volume :
- 15
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Cystic Fibrosis
- Publication Type :
- Academic Journal
- Accession number :
- 115552536
- Full Text :
- https://doi.org/10.1016/j.jcf.2015.09.004