Bazal hücreli kanser gelişiminde füzyon alanlarının rolü var mı?

Background and Design: Basal cell carcinoma (BCC) is the most frequently observed cancer. Its ethiopathogenesis is not totally clarified. In recent years one of the factors mentioned on ethiopathogenesis is 'fusion regions'. In our study we aimed to investigate whether the number of BCC is more or not in anatomic areas which contain more fusion regions. Materials and Methods: Three hundred twenty-eight BCC case whose anatomic region is indicated in histopathology report is taken into study. Fusion regions are determined according to the mapping system given in Tessier's publication. First the number of total fusion region for each anatomic area on face is calculated. Then, the number of BCC located in each anatomic area and the number of fusion region located in the same anatomic area are compared. In conclusion findings are commented with respect to cause result relationship. Results: The most important anatomic areas with respect to fusion region number were forehead and lip. In forehead and lip there were 11 fusion regions. 34 BCC on forehead and 14 BCC on lip are observed. There were 10 fusion regions on around the eye and a total of 74 BCC were observed on both periorbital area. But 9 fusion area is detected on nose area where BCC is mostly present (135). Conclusion: More BCC is not observed in anatomic areas where fusion region is plenty compared to anatomic areas where fusion region is less. As a result; in BCC development, it is seen that only fusion regions do not have ethiopathogenetic importance. [ABSTRACT FROM AUTHOR]