Amiloidosis laríngea: reporte de cuatro casos y revisión bibliográfica.

INTRODUCTION: Amyloidosis is a group of disorders with extracellular amorphous material deposits of unknown etiology and extremely rare. Laryngeal amyloidosis accounts for 0.2 to 1.2% of tumorlike conditions of the larynx. MATERIAL AND METHODS: surgical pathology files of the Hospital Central Sur de Alta Especialidad PEMEX were reviewed and a total of 254 benign lesions in the larynx were found in a period of 14 years, of which 4 are accounted for amyloid deposits (1.57%), all of them adults, 2 men and 2 women. DISCUSSION: extracellular amyloid deposits can be focal or systemic in a tissue or organ. Rarely show remission and progress slowly; are characterized by apple-green birefringence under polarized microscope Congo red staining. The ventricles, ventricular bands and vocal cords are the most common sites of amyloidosis in the respiratory tree can be seen as nodular lesions that occasionally cause pressure effect; seromucus glands are missing, while the squamous epithelium remains intact; often there are mononuclear inflammatory cells, plasma cells predominate in the periphery of amyloid material. CONCLUSION: Laryngeal amyloidosis is a form of localized amyloidosis in our series corresponded to 1.4% of surgical pathology material of this organ. The gold standard for diagnosis is the presence of birefringent deposits with Congo red staining on histopathology. It is important that the clinician knows this entity, and should always be done extension studies to rule out systemic disease. [ABSTRACT FROM AUTHOR]