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Mitochondrial DNA Haplogroup R Confers a Genetic Risk Factor for Intrauterine Adhesion in Han Women Population.
- Source :
-
Gynecologic & Obstetric Investigation . May2016, Vol. 81 Issue 3, p238-243. 6p. 3 Charts. - Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>To determine whether a specific mitochondrial DNA (mtDNA) haplogroup is implicated in the pathogenesis of intrauterine adhesion (IUA).<bold>Methods: </bold>Peripheral blood samples were collected from 486 women with (case group, n = 154) and without IUA (control group, n = 332) at the Women's Hospital, Zhejiang University School of Medicine. Genomic DNA was extracted from the blood, and the mtDNA haplogroups of Han women M, N and R were determined by sequencing hypervariable mtDNA segments and testing diagnostic polymorphisms in the mtDNA coding region.<bold>Results: </bold>Women with mtDNA haplogroup R had an independently increased genetic risk factor for IUA with an OR 1.77 (95% CI 1.16-2.70, p = 0.009) compared with women without. Moreover, repeated intrauterine surgery within 1 month and number of intrauterine operations were both significantly associated with IUA (p < 0.001).<bold>Conclusions: </bold>These results suggest that mtDNA haplogroup R, one of the main mtDNA haplogroups in Han population, is a strong independent genetic risk factor for women with IUA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03787346
- Volume :
- 81
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Gynecologic & Obstetric Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 115853783
- Full Text :
- https://doi.org/10.1159/000439531