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Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta-analysis of 32 case-control studies.
- Source :
-
Molecular & Clinical Oncology . Jun2016, Vol. 4 Issue 6, p1031-1038. 8p. - Publication Year :
- 2016
-
Abstract
- Previous studies suggested that RsaI/PstI and DraI polymorphisms on cytochrome P450 2E1 (CYP2E1) may be associated with susceptibility to gastric cancer (GC). However, this association remains ambiguous. A meta-analysis of previously published studies was performed in an attempt to elucidate this association. The odds ratio and 95% confidence interval were used to assess the strength of the association. In the overall analyses of RsaI/PstI and DraI, no association was identified. In the subgroup analyses, RsaI/PstI was identified to increase the risk of GC in the smoking population. In addition, in the previous studies of interactions with other genes, RsaI/PstI was revealed to be associated with increased GC risks when glutathione S-transferase-μ-1 or glutathione S-transferase θ-1 was null or DraI was homozygous wild-type. However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers. In conclusion, CYP2E1 polymorphisms revealed no association with the risk of GC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *STOMACH cancer risk factors
*CYTOCHROME P-450 CYP2E1
*GENETIC polymorphisms
Subjects
Details
- Language :
- English
- ISSN :
- 20499450
- Volume :
- 4
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Molecular & Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 115899156
- Full Text :
- https://doi.org/10.3892/mco.2016.824