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A Naphthalimide-Based Cd2+ Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET-Promoters under Neutral Conditions.
- Source :
-
Chemistry - A European Journal . 6/13/2016, Vol. 22 Issue 25, p8579-8585. 7p. - Publication Year :
- 2016
-
Abstract
- We have developed a novel naphthalimide-based Cd2+ fluorescent probe ( 1), featuring almost no background response, high sensitivity and selectivity toward Cd2+ through its high association constant [ K=(2.10±0.423)×106], and a practical working pH range. Membrane-permeability was conferred on 1 by replacing the imide and amide substituents with n-butyl groups, and hence the derivative ( 4) has found practical utility on fluorescent imaging of Cd2+ in HeLa cells. Comparison of fluorescent properties between various compounds derived from 1 has demonstrated that the carbamoylmethyl groups in 1 function not only as Cd2+ chelators but also as promoters for photoinduced electron transfer (PET) by lowering the basicity of the two tertiary amino groups. As a result, 1 and 4 exhibited highly practical performance as Cd2+ probes under neutral conditions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 22
- Issue :
- 25
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 115970331
- Full Text :
- https://doi.org/10.1002/chem.201600556