Spectral-domain Optical Coherence Tomography Patterns in Intraocular Lymphoma.

<bold>Purpose: </bold>To examine spectral-domain optical coherence tomography (SD-OCT) patterns in intraocular lymphoma (IOL). <bold>Methods: </bold>Records of 13 patients (21 eyes) with IOL were retrospectively reviewed. SD-OCT was evaluated at initial visit and during follow-up. <bold>Results: </bold>SD-OCT images at initial visit demonstrated disruption of the ellipsoid zone (8 eyes, 38.1%) and hyperreflective nodules at the retinal pigment epithelium (RPE) level (5 eyes, 23.8%). During follow-up, disruption of the ellipsoid zone (10 eyes, 47.6%) and hyperreflective nodules at the RPE level (7 eyes, 33.3%) were noted. In 5 eyes showing hyperreflective nodules at the RPE level, the hyperreflective nodules were reduced after treatment with intravitreal methotrexate. <bold>Conclusions: </bold>Hyperreflective nodules in the outer retina and disruption of the ellipsoid zone were observed in nearly one-half of patients with IOL over time. SD-OCT may allow for early detection of small macular abnormalities and aid in monitoring of treatment efficacy in this disease. [ABSTRACT FROM AUTHOR]