Sensitivity Escherichia coli and Staphylococcus aureus Cause Diarrhea to the Fungi Isolated from Soft Coral.

This study was carried out on four fungi isolated from soft coral to investigate antibacterial activity as new antibiotics for diarrhea-causing bacteria such as Escherichia coli (Migula, 1895) Castellani and Chalmers, 1919 and Staphylococcus aureus Rosenbach, 1884. The present study determined a sensitivity of the extracts was tested on serotyped bacteria E. coli (ATCC 25922), Staphylococcus aureus (ATCC 25953) and wild type pathogenic bacteria. Screening and determination minimum inhibitory concentration (MIC) of the fungi were done by liquid dilution method. Isolates APW/NP-3 (further identified as Aspergillus niger van Tieghem, 1867) showed highest antibacterial activity against two bacterial tested with minimum inhibitory concentration (MIC) of the extract against the E. coli ATCC 25922 and the wild type were 150 mg·L-1 and 300 mg·L-1 respectively. The extract if tested to S. aureus ATCC 25953 and the wild type showed MIC each at 300 mg·L-1 and 600 mg·L-1. This result suggested that extracts from Aspergillus niger could be suitable to treat various infections caused by diarrhea bacteria. [ABSTRACT FROM AUTHOR]