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Regulation of human mesenchymal stem cell differentiation by TREM-2.
- Source :
-
Human Immunology . Jun2016, Vol. 77 Issue 6, p476-482. 7p. - Publication Year :
- 2016
-
Abstract
- Activation of the triggering receptor expressed on myeloid cells 2 (TREM-2) regulates myeloid cell function in vitro. However, the failure to detect TREM-2 protein expression in vivo has hampered studies on immunological and other physiological TREM-2 functions. This study demonstrates that TREM-2 is expressed by human mesenchymal stem cells (h-MSCs) and responds to the toll-like receptor (TLR) ligand lipopolysaccharide (LPS). Knockdown of TREM-2 in h-MSCs using a small interfering RNA (siRNA) reduced the expression levels of TLR2, TLR4, and TLR6, inhibited osteogenic, chondrogenic, and adipogenic differentiation under specific induction conditions, and enhanced LPS-evoked inflammatory cytokine production. Thus, activation of TREM-2 may restrain h-MSC immune activation and promote differentiation for tissue repair. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01988859
- Volume :
- 77
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Human Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 116159937
- Full Text :
- https://doi.org/10.1016/j.humimm.2015.06.005