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Synthesis of superabsorbent hydrogel nanocomposites for use as hemostatic agent.
- Source :
-
International Journal of Polymeric Materials & Polymeric Biomaterials . 2016, Vol. 65 Issue 15, p779-788. 10p. - Publication Year :
- 2016
-
Abstract
- Uncontrolled hemorrhage continues to be the major cause of death in trauma. In this study, the authors prepared hydrogel nanocomposites (HNCs) using three different nanoparticles, SiO2, natural clinoptilolite (nC), and Ca2+-modified clinoptilolite (mC). Fast-swelling superabsorbent hydrogel was used as a matrix of NCs. The hydrogel and HNCs were characterized by FTIR, XRD, FE-SEM, and TGA. The hemocompatibility of HNCs was evaluated by hemolysis test and blood cells function. HNC formed a physical barrier by dehydrating the injury site and concentrating clotting factors. Additionally, highly charged nanoparticles, promoted local hemostasis by activating the intrinsic pathway of the blood coagulation cascade. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEMORRHAGE
*TRAUMATISM
*HEMOSTASIS
*BLOOD coagulation
*HEMOLYSIS & hemolysins
Subjects
Details
- Language :
- English
- ISSN :
- 00914037
- Volume :
- 65
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- International Journal of Polymeric Materials & Polymeric Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 116170860
- Full Text :
- https://doi.org/10.1080/00914037.2016.1171218