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Defective Cyclic Guanosine Monophosphate-gated Calcium Channels and the Pathogenesis of Psoriasis.
- Source :
-
Acta Dermato-Venereologica . Nov2003, Vol. 83 Issue 6, p414-418. 5p. - Publication Year :
- 2003
-
Abstract
- A positive association between intake of calcium channel blockers and psoriasis has been observed recently. Intake of blockers of voltage-gated calcium ion channels is associated with outbreaks of psoriasis after a latent period in patients with and without a previous family history of psoriasis. This suggests that interfering with calcium influx may trigger psoriasis. Calcium influx also occurs via cyclic guanosine monophosphate-gated channels; human keratinocytes contain functional and non-functional (splice variants) versions of these channels. We show here that keratinocytes and skin from psoriatic individuals express higher levels of mRNA encoding a non-functional cyclic guanosine monophosphate-gated calcium channel and that high expression of the splice variant by transfection of cells in culture leads to loss of protein expression for the functional cyclic guanosine monophosphate-gated Ca 2+ channels. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PSORIASIS
*CALCIUM channels
*KERATINOCYTES
*CELL differentiation
*ION channels
Subjects
Details
- Language :
- English
- ISSN :
- 00015555
- Volume :
- 83
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Acta Dermato-Venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 11622660
- Full Text :
- https://doi.org/10.1080/00015550310014726